Complications from the sickle cells blocking blood flow and early breaking apart include:

• Pain episodes
• Strokes
• Increased infections
• Leg ulcers
• Bone damage
• Yellow eyes or jaundice
• Early gallstones
• Lung blockage
• Kidney damage and loss of body water in urine
• Painful erections in men (priapism)
• Blood blockage in the spleen or liver (sequestration)
• Eye damage
• Low red blood cell counts (anemia)
• Delayed growth